Hypoxia-inducible factor-1 alpha (HIF-1α) protein expression is an unfavorable prognostic factor in bladder urothelial carcinoma as it can up-regulate FGFR3, VEGF, and GLUT-1 which contribute to tumor cell survival, tumor angiogenesis, and aerobic glycolysis in response to tumor hypoxia [7–9]. The gene discussed is VEGFA; the disease is neoplasm.