Additionally, GATA3, a transcription factor that was observed to be down-regulated in PBRM1 mutated group in our study, was previously found to be an important early event and potential regulator that associated with loss of TGFβ receptor expression in ccRCC [26, 27] (Fig. 1d). The gene discussed is PBRM1; the disease is nonpapillary renal cell carcinoma.