We systemically compared molecular features in a total of 11 mutated PBRM1 samples with those in 33 “pan-negative” samples; and those samples were all exclusive of any of the five known ccRCC driver genes (VHL, BAP1, SETD2, PTEN and KDM5C) [13, 15]. The gene discussed is KDM5C; the disease is nonpapillary renal cell carcinoma.