TP53 and metastatic neoplasm: We examined the mutational profiles of 53 genes in primary and metastatic tumor samples from 13 patients (Figure 1B and Supplementary Table S1) and identified 56 tumor-specific somatic mutations (mean = 4.3 mutations per patient), including genes with recurrent somatic alterations, e.g., TP53 (92.3%) and FAT3 (23.0%).