In addition, Negri et al.[45] demonstrated a significant association between ERBB2/HER2 oncogene amplification and loss of ATG6/BECN1 (both on 17q21) — a haploinsufficient tumor suppressor that codes for a phylogenetically conserved protein essential for macroautophagy[7, 46]. This evidence concerns the gene ERBB2 and neoplasm.