Interestingly, TIPE2 expression was found to be negatively associated with primary tumor size (P=0.0159), clinical stage (P=0.0128) and lymph node metastasis (LNM) (P=0.0004), which is consistent with our aforementioned findings of IHC. The gene discussed is TIPE2; the disease is metastatic malignant neoplasm in the lymph nodes.