TIPE2 and metastatic malignant neoplasm in the lymph nodes: Results showed that the AUC for TIPE2 in discriminating between cancerous tissues with lymph node metastasis and those without lymph node metastasis was up to 0.935 (Figure 2J, CI (95%): 0.854-0.979, P=0.000), the estimated sensitivity, specificity, PPV and NPV were 78.43%, 100%, 100% and 68.6%, respectively (Supplementary Table S2).