The current study found that stimulation of PADI4 increased CXCR2, KRT14 and TNF-α expression levels, suggesting that increased expression of PADI4 in gastric tumor tissues, as we previously observed, contributes to tumorigenesis by increasing the expression levels of CXCR2, KRT14 and TNF-α. This evidence concerns the gene CXCR2 and gastric neoplasm.