This stimulation resulted in CLL cell enlargement (Supplementary Figure S8A) resembling blastoid transformation and cell cycle entrance, as demonstrated by increased expression of Ki67 and AID (activation-induced cytidine deaminase) genes [33] (Table 3), and Ki67 protein (Supplementary Figure S8B). The gene discussed is MKI67; the disease is B-cell chronic lymphocytic leukemia.