Previous studies reported that canonical Wnt signaling activation, especially nuclear β-catenin importing is one of the common pathways in tumor initiation, as well as in cancer stem cell transformation [21], whereas NF-κB activation triggered by inflammation related signals present in tumor environment may induce dedifferentiation of colon epithelia by inducing Wnt activation [23, 25]. The gene discussed is NFKB1; the disease is cancer.