Although the pro-growth and invasive phenotype of this oncoprotein has been well documented in a wide spectrum of human cancers [12, 14, 19, 22, 38, 39], the present work, to our knowledge, provides the first evidence that CHKA expression is critical for CRC invasion and metastasis in addition to tumor growth, which may explain the observed association between increased CHKA expression and aggressive clinical phenotypes. Here, CHKA is linked to cancer.