CHKA and colorectal carcinoma: Based on CHKA expression and TNM stage status, we classified the 234 CRC patients into three distinct risk groups: Group 1 (low-risk group, both factors low), low CHKA+early TNM stage; Group 2 (intermediate-risk group, one factor high), either low CHKA+advanced TNM stage or high CHKA+early TNM stage; and Group 3 (high-risk group, both factors high), high CHKA+advanced TNM stage.