MTOR and acute myeloid leukemia: Similar to our findings in tNM AML cells, inhibition of MEK and/or PI3K/mTOR in the human AML cell lines blocked cell cycle progression at the G0/G1 phase (Figure 3C) but did not induce apoptosis (Figure 3D), and was also not sufficient to reproduce the effects of suppressing NRAS oncogene expression in the tNM AML model.