Similar to our findings in tNM AML cells, inhibition of MEK and/or PI3K/mTOR in the human AML cell lines blocked cell cycle progression at the G0/G1 phase (Figure 3C) but did not induce apoptosis (Figure 3D), and was also not sufficient to reproduce the effects of suppressing NRAS oncogene expression in the tNM AML model. The gene discussed is NRAS; the disease is acute myeloid leukemia.