DACT2 and neoplasm: For examples, restoration of the expression of Wnt antagonists through either DNA demethylation or histone remodeling results in the blockade of β-catenin-dependent transcription, inhibition of tumor cell proliferation, and induction of tumor cell apoptosis in HCC [10,14,55,77]; and pharmacological demethylation using 5-aza-2′-deoxycytidine leads to the demethylation and expression of SFRPs, DACT2 and WNT10B, reduction of TCF/β-catenin target genes, and apoptosis in cancer cells [55,77,78,79].