BAK1 and cancer: Bcl-2 and cIAP1 protein levels were significantly upregulated, and levels of Bax and Bok were downregulated in Lenti-ILF2 cells; similar results were also validated in siILF2 cells, but there were no changes on Bak levels in cancer cells infected with Lenti-NC and Lenti-ILF2 or transfected with siNC and siILF2 (Figure 5B).