Cancer cells induce the migration of vascular endothelial growth factor receptor 1 (VEGFR1)-positive bone marrow-derived hematopoietic cells to sites of future metastasis where they form cellular clusters preceding tumor cell arrival and increase fibronectin production and matrix stiffness [9], creating a pre-metastatic niche in tissue [8]. This evidence concerns the gene FLT1 and neoplasm.