TP53 and ependymoma: Interestingly, when performing separate pathway analyses for the two different ependymoma cell lines, the pathway of differentially expressed genes bearing the highest level of significance was the p53 pathway in the RELA-positive EP1NS cells (ST-EPN-RELA), whereas for the SJ-BT57 cells (PF-EPN-A), it was the 10th most significant differentially regulated pathway (p = 0.01; Supplementary Figure S9).