Repress expression of tumor suppressor genes (ST7, NM23) Controls growth regulationControl mechanism of p53 responseAccelerates tumor growthContributes to attenuate EGFR-mediated ERK activationLimits the ERK1/2 signalFacilitates PCNA bindingEssential for E-selectin inductionRequired for cellular resistance to DNA damaging stressesActivates NF-κB gene expressionRegulates ribosome biogenesisIncreases growth of hepatocellular carcinoma. The gene discussed is NME1; the disease is hepatocellular carcinoma.