Affects the tumor suppressor ability of BRCA1.Regulates DNA damage responseInitiates BMP-Induced Smad SignalingImpeeds Akt phosphorylationPrerequisite for Akt activationAllows the binding of TDRD3Stabilization from proteosomal degradationNegatively regulates cell apoptosisPrevent the corepressor SIN3A bindingIFNalpha/beta-induced transcriptionRequired for tumor cell migration, invasion and colony formationPromotes mitosisTranscriptional activation of ZEB1 (promotes EMT)Enhances EGF binding, dimerization and signaling activation. The gene discussed is BRCA1; the disease is neoplasm.