Collectively, our study by identifying a PPRE-like sequence within CXCR4 promoter provides the molecular mechanism by which activated PPARγ downregulates CXCR4 expression, thus contributing to explain the negative influence of BRL on breast cancer cell motility and invasion, interfering with the autocrine effects of SDF-1α/CXCR4 system in these cells. This evidence concerns the gene CXCR4 and breast carcinoma.