At the onset of disease, patients < 50 years of age, patients have free immunoglobulin light chains circulating in serum, patients have extramedullary infiltration, patients have higher M protein levels, patients have > 20% plasma cells in the bone marrow smear, β2-MG > 3.5 mg/L, hypercalcemia and increased LDH had higher SUVmax and T/Mmax scores (P < 0.05). This evidence concerns the gene MYOM2 and hypercalcemia disease.