Our results also supported that metastatic melanoma was associated with higher CD147 and GLUT-1 level than primary melanoma (P = 0.006 for CD147, P = 0.036 for GLUT-1; Table 2, Figure 1C-1D), indicating that CD147 and GLUT-1 might play an important role in the development and progression of melanoma. This evidence concerns the gene SLC2A1 and melanoma.