Mutant p53 proteins acquire tumour-promoting functions that enhance cell growth, proliferation, survival, and motility [35, 36] p53 mutations are generally divided into two categories: DNA-interacting mutants that directly alter amino acids and structural mutants that lead to the unfolding of p53 protein, which is critical for tumours to gain tumour-associated functional phenotypes [37, 38]. The gene discussed is TP53; the disease is neoplasm.