However, in a phase II trial of induction CT with weekly cetuximab, paclitaxel, and carboplatin followed by chemoradiation in operable stage III/IV HNSCC, the identification of EGFR by a different approach, i.e. the quantitative AQUA method, confirmed the lack of prognostic value [75]. The gene discussed is EGFR; the disease is head and neck squamous cell carcinoma.