Besides its binding to and inhibition of telomerase, other mechanisms of these functions also been found, for example: the regulation of telomerase activity by PinX1 in gastric cancer is involved in Mad/c-Myc pathway [84], and the role of PinX1 in telomerase function regulation is mediated by cycle-dependent localization of telomerase to telomere [85]. The gene discussed is PINX1; the disease is gastric cancer.