Interestingly, knockdown of PinX1 dramatically enhanced paclitaxel cytotoxicity to cervical squamous cell carcinomas cells [83] and knockdown of PinX1 substantially increased ESCC (oesophageal squamous cell carcinoma) cells' therapeutic efficacy of radiation both in vitro and in vivo. The gene discussed is PINX1; the disease is esophageal squamous cell carcinoma.