TERT and cancer: On the other hand, telomerase in general and its TERT subunit in particular can regulate other various hallmarks of cancer [10], such as regulation of sustaining proliferative signaling [11-14], modulation of angiogenesis [15-19], resistance to apoptosis [20, 21], participation of invasion and metastasis [22-24], maintaining genome stability [25, 26] and so on.