Interestingly, knockdown of PinX1 dramatically enhanced paclitaxel cytotoxicity to cervical squamous cell carcinomas cells [83] and knockdown of PinX1 substantially increased ESCC (oesophageal squamous cell carcinoma) cells' therapeutic efficacy of radiation both in vitro and in vivo. Here, PINX1 is linked to cervical squamous cell carcinoma.