However, many questions remained to be addressed including what are the functions of G-patch of PinX1, how PinX1 regulates tumorigenesis and tumor progression, what induce the functions of PinX1 to be tumor-type-specific, how to develop PinX1-based cancer diagnosis and individualized treatment, and whether PinX1 has other new functions. This evidence concerns the gene PINX1 and cancer.