To examine the mechanistic basis of Ets2 in ESCC, we determined the effects of Ets2 knockdown on the expression of phosphorylated mTOR (p-mTOR), p70S6K and Prdx1 of ESCC cell in vitro and cancer xenograft mouse model. The gene discussed is PRDX1; the disease is esophageal squamous cell carcinoma.