ETS2 and lung cancer: Expression of Ets2 is not observed in normal colon and hyperplastic polyps, however its expression is associated with advancing tumor grade and correlates with lymph node metastasis in colon cancer [17], and Ets2 deregulated in non-small cell lung cancer was identified as one of 50 genes in mice that are involved in the progression of lung cancer from adenoma to carcinoma [22].