SDF1-CXCR4 signaling is also involved in migration of cancer cells to the sites of metastasis (SDF1-expressing tissues, such as bone marrow and lung) including breast, lung, ovarian, thyroid, rhabdomyosarcoma and others (over 20 human tumor types (reviewed in [86]) [53, 87, 86–89]. Here, CXCL12 is linked to cancer.