DUX4 and rhabdomyosarcoma: These functional categories have already been attributed to DUX4 target genes in previous transcriptomic studies of genes differentially expressed in DUX4-overexpressing murine C2C12 myoblasts [14], human primary myoblasts [12] and rhabdomyosarcoma cells [47]; furthermore, functional involvement of ectopically expressed DUX4 in certain aspects of cellular metabolism and regulation of apoptosis has been previously demonstrated [13, 14].