Inflammation before tumor arised in DDB1F/F, Alb-Cre+/− and DEN mouse model was assessed, as shown in Figure 4A, by IHC for biomarkers of leukocytes(CD45) and macrophage (F4/80), more inflammatory cells in 12 months old DDB1F/F, Alb-Cre+/− mouse than age-matched control were observed, while no difference of inflammatory cells between DEN-treated and age-match control. Here, ALB is linked to neoplasm.