Several upstream regulator drugs are found to regulate multiple genes in this group, among them, Ethinyl estradiol, an orally bioactive estrogen, regulates ABCB11, CCR7, CD97, CYP2D6, CYP7B1, SGK1, suggesting although being ER-negative, estrogen may still play a role in this group of patients; the drug, which is used to treat myelodsyplastic syndromes and acute myeloid leukemia, regulates BMP4, CCR7, MAGEC1, METAP2, MGMT, RARB, RARRES1, SGK1, SNRPN, and TGFBR2 [10, 11]. Here, ESR1 is linked to acute myeloid leukemia.