ACHE and Cognitive impairment: As shown in Figure 3(a), SCOP caused a remarkable increase of AChE activity in both hippocampus (1.43 ± 0.19%) and cortex (1.41 ± 0.17%), suggesting that the dysfunction of cholinergic nervous system may facilitate the process of cognitive impairment, while the treatment with STS and Donepezil significantly decreased the AChE activity.