TNF and rheumatoid arthritis: Our study has the following advantages: (1) the clinical response was pooled at different time points, respectively, which avoided potential bias generated from drug effect varied by different time points; (2) subgroup analyses stratified by TNFi types and assay methods for ADAb detection were performed, contributing to exploration of more precise correlations between ADAb+ and response to specific anti-TNF drugs in RA patients; (3) no obvious publication bias was observed in this meta-analysis, indicating the reliability of our results.