SEMA3E and neoplasm: In addition, RhoJ is also important for vascularisation [11, 14, 15], especially for tumor angiogenesis [16, 17]; RhoJ is the common downstream target of the Sema3E signals [11] in regulating retinal vascularisation; the knockdown of RhoJ causes a double assault on tumor vessels by both the inhibition of angiogenesis and vascular disruption [16].