Pfeifer et al. [17] described 8 CHEK2 mutation carriers receiving neoadjuvant therapy, with none of them achieving pathologic complete response; 4 out of these 8 women experienced objective clinical response, however the reduction of the tumor size was observed only in 1 out of 4 patients treated by anthracycline-based therapy without taxanes. The gene discussed is CHEK2; the disease is neoplasm.