CYP3A4 and infection: Current literature suggests that severity of hypoxia, acidosis and exertion of respiratory muscles, infections and/or electrolyte imbalance, the use of mechanical ventilation, prolonged CPR, large dosages of corticosteroids or theophylline in combination with NMBAs or CYP3A4 (such as macrolides), sedation with propofol, older age, and underlying myopathy may be the risk factors for rhabdomyolysis in patients with status asthmaticus.