For example, in subjects with prediabetes, the hypermethylated genes were CHUK, TRIM38, PLK2, TNFRSF19, and ZMYND11, while in subjects with diabetes they were BCL3, IL23A, F2RL1, S100A12, TNFRSF10B, NEK6, RNF31, SLC35B2, and IRAK1BP1. Here, NEK6 is linked to diabetes mellitus.