For example, in subjects with prediabetes, the hypermethylated genes were CHUK, TRIM38, PLK2, TNFRSF19, and ZMYND11, while in subjects with diabetes they were BCL3, IL23A, F2RL1, S100A12, TNFRSF10B, NEK6, RNF31, SLC35B2, and IRAK1BP1. The gene discussed is F2RL1; the disease is prediabetes syndrome.