For example, in subjects with prediabetes versus controls, cytochrome P450, family 4, subfamily F, polypeptide 3 (CYP4F3), CYP4F8, Phospholipase A2, group IIC (PLA2G2C), and PLA2G4E were differentially methylated, while in subjects with diabetes versus prediabetes, CYP2E1 and PLA2G12A were involved. Here, PLA2G4E is linked to prediabetes syndrome.