For example, in subjects with prediabetes, the hypermethylated genes were CHUK, TRIM38, PLK2, TNFRSF19, and ZMYND11, while in subjects with diabetes they were BCL3, IL23A, F2RL1, S100A12, TNFRSF10B, NEK6, RNF31, SLC35B2, and IRAK1BP1. This evidence concerns the gene PLK2 and prediabetes syndrome.