TNF and neoplasm: Examples of key players of cancer-related inflammation (CRI) include tumor-infiltrating lymphocytes, tumour-associated macrophages (TAMs), the secretion of cytokines such as TNF, IL-1, IL-6, and chemokines such as CCL2 and CXCL8, in addition to the occurrence of tissue remodeling and angiogenesis (Colotta et al., 2009).