Bevacizumab is a humanized mAb that targets to the vascular endothelial growth factor (VEGF) antigen (Presta et al., 1997; Ferrara et al., 2005), which is widely over expressed in a variety of human solid tumors and plays a key role in tumor angiogenesis (Ellis and Hicklin, 2008; Goel and Mercurio, 2013; Domigan et al., 2015). The gene discussed is VEGFA; the disease is neoplasm.