Akin to the roles that lymphotoxin signaling plays in the control of PNAd expression in SLO, LTα3-dependent signaling has been reported to dominantly control PNAd expression on HEV within the tumor microenvironment (TME) in murine melanoma models (32), while in human breast cancer, LTβ (produced by DC-LAMP + DC) appears to play a comparable dominant role (33). The gene discussed is NTAN1; the disease is breast cancer.