Recently, Fernandez-Enright et al. (2014) have provided the first evidence of an implication of Lingo1 in schizophrenia, by observing alterations in the expression profiles of Lingo1 and their signaling partner proteins in the dorsolateral prefrontal cortex and CA1–CA3 hippocampal areas of post-mortem schizophrenia brains, two regions highly disrupted in this pathology. Here, LINGO1 is linked to schizophrenia.