Th17 cells are strictly connected to the pathogenesis of MS through, but not limited to, the production of several proinflammatory cytokines including IL-17 (A and F), which has been found upregulated in chronic lesions of MS patients [20] and in the serum of Interferon-β (IFN-β) nonresponding patients [21]. Here, IFNB1 is linked to myeloid sarcoma.