No association was found between the IL-10 Receptor B (IL-10RB) polymorphism rs2834167 and depression in lung cancer patients (Reyes-Gibby, 2013b), but Lys47Glu (rs2834167) was associated with a symptom cluster of pain, depressed mood, and fatigue when combined with other mutant alleles (Reyes-Gibby, 2013a). This evidence concerns the gene IL10RB and major depressive disorder.