Tartter et al (2015) also found that CC carriers for IL-6 174 were more likely to experience depressive symptomatology following chronic interpersonal stress, but not other stressors. They also noted that 174G confers protection against inflammation in adolescence, but increases the risk for inflammation in adulthood, possibly indicating an age-dependent function. Roetker et al (2012) found that women homozygous (CC/GG) for rs1800795 had an increased risk of depression, but only in the presence of other risk genes. Here, IL6 is linked to major depressive disorder.