CXCL8 and depressive disorder: Kim et al (2013a) also investigated IL-8-251T/A in breast cancer patients and again found no association between either of the alleles and depression. The same research team later found a relationship between increasing numbers of physical disorders and incident late-life depression in those with the IL-8 251A variant in the aforementioned study (Kim et al, 2013b). Kang et al (2014), however, found no association between IL-8 −251T/A and depression in a study of 732 elderly Koreans.