Hsp27 is overexpressed across different cancers like prostate, breast, ovarian and gastric3, 4, 5, 6, 7, 8 and contributes to cancer progression via different mechanisms; aside from its anti-apoptotic and pro-survival activities which play crucial parts in tumorigenesis9, Hsp27 increases proliferation by facilitating cell cycle progression1, and enhances migration and invasion via multiple mechanisms10, 11. This evidence concerns the gene HSPB1 and cancer.