These in vitro findings were supported by clinical data showing that expression of Hsp27 (HSPB1) and a subset of these YAP/TAZ target genes (Supplementary Table S2) were positively correlated in the publicly available TCGA database for prostate cancer tissues29 (Fig. 1f, The Cancer Genome Atlas, https://genome-cancer.ucsc.edu/). Here, HSPB1 is linked to Familial prostate cancer.