YAP1 and neoplasm: In normal cells, LATSs are responsible for phosphorylation of the transcriptional co-activators YAP1 (Yes associated protein) and its paralogue, TAZ (transcriptional co-activator with PDZ-binding motif) which results in their cytoplasmic sequestration with the 14.3.3 proteins and prevents their association with pro-tumor transcription factors19.