MGMT and neoplasm: In univariate analyses, factors significantly associated with poor OS (online research table S2) were larger BTV (for all three TBR’s P < 0.001), higher TBRmean (P < 0.001), higher TBRmax (P < 0.001), older age (P = 0.002), WHO PS 1 vs. 0 (P < 0.001), WHO PS 2 vs. 0 (P < 0.001), use of corticosteroids ≥ 15 mg (P = 0.001), MGMT protein-positive (P < 0.001) and contrast-enhancing tumor volume on MRI (P < 0.001).