PRKN and Cerebral ischemia: Studies have also demonstrated that Parkin could be translocated to mitochondria during reperfusion and that ischemia-induced neuronal injury was aggravated after administration of mitophagy inhibitor mdivi-1 in the reperfusion phase, suggesting that mitophagy underlies the neuroprotection that occurred in the process of cerebral ischemia reperfusion (Zhang et al., 2013).