NFE2L2 and amyotrophic lateral sclerosis: Intriguingly, in a zebrafish model expressing mutant SOD1 the approved ALS drug riluzole and an activator of Nrf2 (apomorphine) reduced the early neuronal stress response observed in motor neurones (McGown et al., 2013) further highlighting Nrf2 signalling as an attractive potential therapeutic target (Milani et al., 2013).