Further, the RNA binding protein RBM45 also modulates the antioxidant cell response through stabilising Keap1 impeding the protective antioxidant response and increased levels of RBM45 have been found in the cerebral spinal fluid of ALS patients with the protein localising to cytoplasmic inclusions in motor neurones (Bakkar et al., 2015, Li et al., 2015). Here, KEAP1 is linked to amyotrophic lateral sclerosis.