NFE2L2 and Parkinson disease: In this study, by using chronic oral rotenone treatment as an in vivo PD model, we explored the effectiveness of sulforaphane against rotenone-induced motor deficits and dopaminergic neuron loss; we also determined whether the possible underlying mechanisms of its effects were associated with Nrf2-regulated anti-oxidative, mTOR-mediated anti-apoptotic, and/or autophagy systems.