As shown in Table 3, VDR ApaI polymorphism was not significantly correlated with prostate cancer risk in pooled analysis of eligible studies (homozygote model: AA vs. aa, OR = 0.97, 95 % CI: 0.76–1.25, P = 0.85; heterozygote model: Aa vs. aa: OR = 1.00, 95 % CI: 0.88–1.13, P = 0.99; dominant model: AA + Aa vs. aa: OR = 0.98, 95 % CI: 0.87–1.10, P = 0.79, Fig. 2; recessive model: AA vs. Aa + aa: OR = 0.97, 95 % CI: 0.85–1.01, P = 0.64). This evidence concerns the gene VDR and Familial prostate cancer.