These SNPs show trans association with differential expression following heat shock of UBQLN1 (ubiquilin), an important mediator of degradation of proteins in the stress response [54] implicated in Alzheimer’s disease [55], and a network of six further genes including HSF1. However, we did not observe cis-associations with expression of MINPP1 and CDKN1A which leaves unresolved the cis-drivers of the observed trans associations. This evidence concerns the gene HSF1 and early-onset autosomal dominant Alzheimer disease.