The comparison of wild-type and mutated settings revealed differential distributions of CNA-IC50 correlations for the CTNNB1, EGFR, ERBB2, and PIK3CA (analyzed jointly with PIK3R1) proto-oncogenes and for the PTEN, RB1, TSC1/2, and VHL tumor suppressors (Fig. 4a shows results for PIK3CA/PIK3R1 status; and Additional files 6 and 7). The gene discussed is RB1; the disease is neoplasm.