BRCA1 and breast carcinoma: In order to determine the utility of genetic testing for BRCA1 and BRCA2 germline mutations for women with TNBC in Pakistan, we comprehensively screened both genes for small-range mutations as well as large genomic rearrangements in a group of 523 breast cancer patients who were selected based on early-age of disease onset or family history of breast/ovarian cancer, including 192 patients diagnosed with TNBC.