In this regard, the panel consisting of CXXC4, DACT2, HHIP, ZIC1, and ZIC4 is a promising starting point for the development of a prognostic epimarker panel based on the finding that the MI value in tumor samples moderately correlated with the overall time of survival in the subgroup of 18 OSCC patients who died of the disease. The gene discussed is CXXC4; the disease is neoplasm.