NPM1 and hepatocellular carcinoma: Overall, NPM1 overexpression is linked to high grade tumors and poor prognosis, as observed in brain glioblastoma [79], oral squamous cell carcinoma [80], non-small cells lung cancer (NSCLC) [51], hepatocellular carcinomas (HCC) [81], colon cancer [82–84], ovarian cancer [62, 85], and endometrial carcinoma [86].