In addition, an Australian case–control genetic study (774 esophageal cancer cases vs 1352 controls) found no correlation of the obesity-related ghrelin SNPs sampled (rs468677 (L90Q), rs696217 (M72L)) with esophageal cancer incidence (Doecke et al. 2008). The gene discussed is GHRL; the disease is obesity due to melanocortin 4 receptor deficiency.