A Polish and German study of various hormonal gene SNPs with a proven or potential functional effect, in 798 breast cancer cases and 1011 controls, found a decreased risk of cancer associated with two rare ghrelin haplotypes, GGAC (OR: 0.05, 95% CI: 0.01–0.79; P=0.001) and GGAT (OR: 0.23, 95% CI: 0.04–1.13; P=0.04) (Wagner et al. 2006). This evidence concerns the gene GHRL and breast carcinoma.