However, other substantial clinical trial and meta-analysis data have shown no association of IGF1 or its binding proteins (e.g. IGF-binding protein 3 (IGFBP3)) with breast, prostate or colorectal cancers (Renehan et al. 2006, Schernhammer et al. 2006, Severi et al. 2006, Mikami et al. 2009, Rowlands et al. 2012, Yoon et al. 2015), although a positive correlation of insulin/hyperinsulinemia with advanced colorectal cancer has been noted (Yoon et al. 2015). This evidence concerns the gene IGFBP3 and Hyperinsulinemia.