Three of the studies reported significantly reduced ghrelin levels in CP patients vs controls (Holmer et al. 2010, Roth et al. 2011, Roemmler-Zehrer et al. 2014), and two reported a significant inverse association of serum ghrelin level with CP tumor growth (Trivin et al. 2009, Holmer et al. 2010). Here, GHRL is linked to neoplasm.