In the present study, we used 356 cases in The Cancer Genome Atlas (TCGA) database and a tissue microarray (TMA) including 276 well-documented, clinically annotated CRC specimens in Fudan University Shanghai Cancer Center (FUSCC) to investigate the expression of PD-1 and PD-L1 in CRC and their clinical significance. Here, CD274 is linked to colorectal carcinoma.